abstract：BACKGROUND:Many countries have various requirements for local economic analyses to assess the value of a new health technology and/or to secure reimbursement. This study presents a case study of an economic model developed to assess the cost-effectiveness of posaconazole vs standard azole therapy (fluconazole/itraconaz...

journal_title：Journal of medical economics

authors： Papadopoulos G,Hunt S,Prasad M

更新日期：2013-01-01 00:00:00

abstract：OBJECTIVE:A new and smaller percutaneous ventricular assist device (pVAD, Impella, Abiomed, Danvers, MA) has been developed to provide circulatory support in hemodynamically unstable patients and to prevent hemodynamic collapse during high-risk percutaneous coronary interventions (PCI). The objective of the study was t...

journal_title：Journal of medical economics

authors： Roos JB,Doshi SN,Konorza T,Palacios I,Schreiber T,Borisenko OV,Henriques JP

更新日期：2013-01-01 00:00:00

abstract：OBJECTIVE:To estimate the cost-effectiveness of ipilimumab (3 mg/kg) compared with best supportive care (BSC) in pre-treated advanced melanoma patients. METHODS:The analysis was based on a US payer perspective and lifetime time horizon. A three-state Markov model was developed representing clinical outcomes, quality-o...

journal_title：Journal of medical economics

authors： Barzey V,Atkins MB,Garrison LP,Asukai Y,Kotapati S,Penrod JR

更新日期：2013-01-01 00:00:00

abstract：OBJECTIVE:To describe costs, healthcare resource utilization, and adherence of US patients receiving human regular U-500 insulin (U-500R), compared to patients receiving high-dose (>200 units/day) U-100 insulins (U-100) by subcutaneous injection for the treatment of diabetes. METHODS:A retrospective analysis of data f...

journal_title：Journal of medical economics

authors： Eby EL,Wang P,Curtis BH,Xie J,Haldane DC,Idris I,Peters AL,Hood RC,Jackson JA

更新日期：2013-01-01 00:00:00

abstract：OBJECTIVES:Non-severe nocturnal hypoglycemic events (NSNHEs) may have a major impact on patients. The objective was to determine how NSNHEs affect diabetes management, sleep quality, functioning, and to assess if these impacts differ by diabetes type or country. METHODS:An internet survey to adults with diabetes in th...

journal_title：Journal of medical economics

authors： Brod M,Christensen T,Bushnell DM

更新日期：2012-01-01 00:00:00

abstract：OBJECTIVE:Abdominal paracentesis is commonly performed for diagnostic, therapeutic, and palliative indications, but the use of ultrasound guidance for these procedures is relatively recent, variable, and not well documented. A retrospective database analysis of abdominal paracentesis procedures was performed to determi...

journal_title：Journal of medical economics

authors： Patel PA,Ernst FR,Gunnarsson CL

更新日期：2012-01-01 00:00:00

abstract：OBJECTIVE:Duloxetine is indicated for treatment of major depressive disorders in the UK. While clinical trials have documented its clinical effectiveness, little is known regarding the relationship between duloxetine use and healthcare utilization in community practice. This study quantifies the impact of treatment wit...

journal_title：Journal of medical economics

authors： Shi N,Cao Z,Durden E,Schacht A,Torres A,Happich M

更新日期：2012-01-01 00:00:00

abstract：OBJECTIVE:To estimate direct medical costs and resource use for commercially-insured patients within two pulmonary hypertension sub-groups: pulmonary arterial hypertension (PAH) and chronic thromboembolic pulmonary hypertension (CTEPH). RESEARCH DESIGN AND METHODS:Using a retrospective cohort design, subjects (≥18 yea...

journal_title：Journal of medical economics

authors： Said Q,Martin BC,Joish VN,Kreilick C,Mathai SC

更新日期：2012-01-01 00:00:00

abstract：OBJECTIVE:To evaluate the cost-effectiveness of biphasic insulin lispro mix 75/25 (LM75/25) and mix 50/50 (LM50/50) compared with a long-acting analog insulin (LAAI) regimen from the perspective of a US healthcare payer. METHODS:A published computer simulation model of diabetes was used to evaluate the cost-effectiven...

journal_title：Journal of medical economics

authors： Pollock RF,Curtis BH,Valentine WJ

更新日期：2012-01-01 00:00:00

abstract：OBJECTIVE:Basal insulin analogs are well established in the treatment of type 1 diabetes in Germany. However, little is known about their economic impact. The aim of this study for an adult population was to compare, from the perspective of the Statutory Health Insurance (SHI), the cost effectiveness of the long-acting...

journal_title：Journal of medical economics

authors： Pfohl M,Schädlich PK,Dippel FW,Koltermann KC

更新日期：2012-01-01 00:00:00

abstract：OBJECTIVE:To estimate the economic implications of introducing dabigatran etexilate ('dabigatran') for anti-coagulation therapy in Danish patients with non-valvular atrial fibrillation based on results of the RE-LY trial. METHODS:The lifetime cost and outcomes of dabigatran and warfarin were estimated using a previous...

journal_title：Journal of medical economics

authors： Langkilde LK,Bergholdt Asmussen M,Overgaard M

更新日期：2012-01-01 00:00:00

abstract：OBJECTIVE:To compare rates of severe relapse and total direct and indirect costs over a 2-year period between US-based employees with multiple sclerosis (MS) who were adherent and non-adherent to disease-modifying drugs (DMDs). METHODS:Employees with ≥1 MS diagnosis (ICD-9-CM: 340.x) and ≥1 DMD pharmacy claim between ...

journal_title：Journal of medical economics

authors： Ivanova JI,Bergman RE,Birnbaum HG,Phillips AL,Stewart M,Meletiche DM

更新日期：2012-01-01 00:00:00

abstract：OBJECTIVES:To describe treatment patterns and healthcare burden among individuals with suspected pulmonary arterial hypertension (PAH), as identified through a practice guideline-based healthcare claims algorithm. METHODS:Adults with evidence of PAH from 1 January 2004 (commercial and Medicaid) or 1 July 2006 (Medicar...

journal_title：Journal of medical economics

authors： Copher R,Cerulli A,Watkins A,Laura Monsalvo M

更新日期：2012-01-01 00:00:00

abstract：OBJECTIVE:The spectrum of diseases caused by Streptococcus pneumoniae and non-typeable Haemophilus influenzae (NTHi) represents a large burden on healthcare systems around the world. Meningitis, bacteraemia, community-acquired pneumonia (CAP), and acute otitis media (AOM) are vaccine-preventable infectious diseases tha...

journal_title：Journal of medical economics

authors： Knerer G,Ismaila A,Pearce D

更新日期：2012-01-01 00:00:00

abstract：BACKGROUND:Percutaneous pulmonary valve implantation (PPVI) using the Melody * transcatheter pulmonary valve is a new procedure introduced in 2000 as a less invasive treatment for right ventricular outflow tract (RVOT) dysfunction. The aim of this new procedure is to restore pulmonary valve competence without the need ...

journal_title：Journal of medical economics

authors： Raikou M,McGuire A,Lurz P,Bonhoeffer P,Wegmueller Y

更新日期：2011-01-01 00:00:00

abstract：PURPOSE:The purpose of this study was to describe the health-related quality-of-life (QoL) in patients after elective surgery for abdominal aortic aneurysm (AAA) compared to a normal population and to study the association between QoL and number of years since surgery. METHODS:All Danish men who underwent elective sur...

journal_title：Journal of medical economics

authors： Ehlers L,Laursen KB,Jensen MB

更新日期：2011-01-01 00:00:00

abstract：AIMS:Fast-acting insulin analogues (FAIAs) reduce hypoglycaemia and improve administration flexibility compared with short-acting human insulin (SHI). This analysis examines whether these benefits translate into cost offsets when comparing the total treatment costs for FAIA versus SHI used as basal-bolus therapy for tr...

journal_title：Journal of medical economics

authors： Christensen TE,Gundgaard J,Pilgaard T

更新日期：2011-01-01 00:00:00

abstract：OBJECTIVE:This study evaluated the overall burden of illness of chemotherapy-induced nausea and vomiting (CINV) and associated all-cause costs from a hospital's perspective (costs to the hospital) in patients with cancer treated with chemotherapy (CT) in the US hospital outpatient setting. METHODS:Patients with a canc...

journal_title：Journal of medical economics

authors： Craver C,Gayle J,Balu S,Buchner D

更新日期：2011-01-01 00:00:00

abstract：BACKGROUND:In the last decade, the number of new agents, including monoclonal antibodies, being developed to treat metastatic colorectal cancer (mCRC) increased rapidly. While improving outcomes, these new treatments also have distinct and known safety profiles with toxicities that may require hospitalizations. However...

journal_title：Journal of medical economics

authors： Overbeek JA,Zhao Z,van Herk-Sukel MP,Barber BL,Gao S,Herings RM

更新日期：2011-01-01 00:00:00

abstract：OBJECTIVE:The relationship between chronic noncancer pain (CNCP) control and pain medication (analgesic) adherence has not been widely documented. The primary aim of this study was to evaluate the relationship between pain intensity and the degree of adherence to analgesic medication prescribed in pain clinics. There w...

journal_title：Journal of medical economics

authors： Stern A,Sánchez-Magro I,Rull M

更新日期：2011-01-01 00:00:00

abstract：OBJECTIVES:To perform a cost-utility analysis of a new formulation of mesalazine (Mezavant XL, MMX mesalazine) versus an existing oral mesalazine (Asacol; mesalazine) from the UK National Health Service perspective. METHODS:A 5-year Markov cohort model was developed. Costs were obtained from the literature and utiliti...

journal_title：Journal of medical economics

authors： Brereton N,Bodger K,Kamm MA,Hodgkins P,Yan S,Akehurst R

更新日期：2010-03-01 00:00:00

abstract：OBJECTIVE:Reduction in health-related quality of life is common in children born small for gestational age (SGA) or children with growth hormone deficiency (GHD). Growth hormone treatment with somatropin in these children leads to normalisation of height. The aim of this study was to determine whether somatropin is a c...

journal_title：Journal of medical economics

authors： Christensen T,Fidler C,Bentley A,Djurhuus C

更新日期：2010-03-01 00:00:00

abstract：OBJECTIVE:To quantify the health economic impact of managing cow milk allergy (CMA) in South Africa, from the perspective of healthcare insurers in both the private and public sectors and parents/carers of CMA sufferers. METHODS:A decision model depicting the management of CMA in South Africa was constructed, using in...

journal_title：Journal of medical economics

authors： Sladkevicius E,Guest JF

更新日期：2010-01-01 00:00:00

abstract：OBJECTIVE:To study outcomes of multiple sclerosis (MS) patients treated with either glatiramer acetate (Copaxone) or interferon beta-1a for once-weekly, intramuscular administration (Avonex). METHODS:An 'intent-to-treat' (ITT) cohort (n=1282) was established, consisting of patients diagnosed with MS who began therapy ...

journal_title：Journal of medical economics

authors： Castelli-Haley J,Oleen-Burkey MA,Lage MJ,Johnson K

更新日期：2010-01-01 00:00:00

abstract：OBJECTIVE:To estimate health-related quality of life (HRQoL) in non-growth hormone deficient (GHD) small for gestational age (SGA) children before and after growth hormone (GH) treatment to adult height (AH). METHODS:This was a multicentre, two-arm trial. Following an initial 2-year double-blind study period, patients...

journal_title：Journal of medical economics

authors： Bannink E,Djurhuus CB,Christensen T,Jøns K,Hokken-Koelega A

更新日期：2010-01-01 00:00:00

abstract：OBJECTIVE:Two human papillomavirus (HPV) vaccines are on the market. Based on expected differences in sustained- and cross-protection between the two vaccines, their long-term economic value is modelled and compared for France, Ireland and Italy. METHODS:A Markov cohort model reproducing the natural history of HPV inf...

journal_title：Journal of medical economics

authors： Demarteau N,Standaert B

更新日期：2010-01-01 00:00:00

abstract：OBJECTIVE:Prostate cancer is a leading cause of cancer death in men in the US. Castration-resistant prostate cancer (CRPC) is an advanced form of the disease and has a poor prognosis and limited treatment options. The objective of this study was to identify patients with CRPC from a medical claims database, and determi...

journal_title：Journal of medical economics

authors： Alemayehu B,Buysman E,Parry D,Becker L,Nathan F

更新日期：2010-01-01 00:00:00

abstract：OBJECTIVES:To compare demographic and comorbidity profiles and healthcare costs of Medicaid patients with postherpetic neuralgia (PHN) treated with lidocaine patch 5% (lidocaine patch) versus patients not treated with the lidocaine patch. Repeat comparison for the subset of patients treated in long-term care (LTC) sett...

journal_title：Journal of medical economics

authors： Kirson NY,Ivanova JI,Birnbaum HG,Wei R,Kantor E,Amy Puenpatom R,Ben-Joseph RH,Summers KH

更新日期：2010-01-01 00:00:00

abstract：OBJECTIVE:To critically evaluate published cost-effectiveness studies of novel drug products requiring less-frequent medication dosing compared to conventional formulations of the same drug substance. METHODS:A search was conducted in the Medline and Embase databases for cost-effectiveness studies published before May...

journal_title：Journal of medical economics

authors： Cheng MM,Alfonso R,Best JH,Garrison LP,Bruhn D,Veenstra DL

更新日期：2010-01-01 00:00:00

abstract：OBJECTIVE:Few studies have examined the costs associated with differing first-line chemotherapy regimens in patients with metastatic breast cancer (MBC). This study compares the relative cost impact of women starting first-line chemotherapy with capecitabine versus taxanes. METHODS:Women receiving first-line chemother...

journal_title：Journal of medical economics

authors： Camacho FT,Wu J,Wei W,Kimmick G,Anderson RT,Balkrishnan R

更新日期：2009-09-01 00:00:00

abstract：OBJECTIVE:A cost analysis of once-daily insulin glargine versus three-times daily insulin lispro in combination with oral antidiabetic drugs (OADs) for insulin-naive type 2 diabetes patients in Germany based on the APOLLO trial (A Parallel design comparing an Oral antidiabetic drug combination therapy with either Lantu...

journal_title：Journal of medical economics

authors： Bretzel RG,Dippel FW,Linn T,Neilson AR

更新日期：2009-06-01 00:00:00

abstract：OBJECTIVE:Cost-effectiveness analyses of new treatments for cardiovascular disease frequently require input parameters whose values are known with uncertainty due to limited data. The objective of this paper is to examine the extent to which published sensitivity analyses addressing this uncertainty adhere to Health Te...

journal_title：Journal of medical economics

authors： Mauskopf JA,Boye KS,Schmitt C,McCollam P,Birt J,Juniper MD,Bakhai A

更新日期：2009-06-01 00:00:00

abstract：OBJECTIVE:To estimate the lifetime economic consequences of glaucoma in France. METHODS:A Markov model estimated the average discounted outcome and cost of glaucoma treatment over a patient's lifetime. Clinical states were defined as first- to fourth-line drugs, no treatment, laser therapy, surgery, blindness and deat...

journal_title：Journal of medical economics

authors： Philippe Nordmann J,Lafuma A,Berdeaux G

更新日期：2009-03-01 00:00:00

abstract：OBJECTIVES:The first objective was to assess the effect of the chondroitin 4 and 6 sulphate (CS) on health-related quality of life using utility values in patients with knee osteoarthritis (OA) during a 24-month treatment course. The second objective was, using these data, to conduct economic analyses. METHODS:Data fr...

journal_title：Journal of medical economics

authors： Bruyère O,Scholtissen S,Neuprez A,Hiligsmann M,Toukouki A,Reginster JY

更新日期：2009-01-01 00:00:00

abstract：OBJECTIVES:To assess the costs of severe hypoglycaemic events (SHEs) in diabetes patients in Germany, Spain and the UK. METHODS:Healthcare resource use was measured by surveying 639 patients aged ≥ 16 years, receiving insulin for type 1 (n=319) or type 2 diabetes (n=320), who experienced ≥ 1 SHE in the preceding year....

journal_title：Journal of medical economics

authors： Hammer M,Lammert M,Mejías SM,Kern W,Frier BM

更新日期：2009-01-01 00:00:00

abstract：OBJECTIVES:To assess the cost effectiveness of palivizumab, a humanised monoclonal antibody, used as prevention against severe respiratory syncytial virus (RSV) infection requiring hospitalisation, in infants with haemodynamically significant congenital heart disease (CHD) in the German healthcare setting. STUDY DESIG...

journal_title：Journal of medical economics

authors： Nuijten M,Lebmeier M,Wittenberg W

更新日期：2009-01-01 00:00:00

abstract：OBJECTIVE:The objective of this study was to describe the economic burden to managed care associated with failure of selective serotonin reuptake inhibitor (SSRI) therapy in terms of direct medical costs. METHODS:A retrospective analysis of the PharMetrics database, a national managed care medical and pharmacy claims ...

journal_title：Journal of medical economics

authors： Balkrishnan R,Joish VN,Yang T,Jayawant SS,Mullins CD

更新日期：2008-01-01 00:00:00

abstract：OBJECTIVE:This analysis was conducted to compare the direct medical costs of treatment with darbepoetin alfa every 3 weeks (Q3W) and epoetin alfa every week (QW) in patients with chemotherapy-induced anaemia (CIA) from the payer's perspective. METHODS:An analysis was conducted from a US health plan perspective to comp...

journal_title：Journal of medical economics

authors： Rubin RJ,Glaspy JA,Adams JL,Mafilios MS,Wang SM,Viswanathan HN,Kallich JD

更新日期：2008-01-01 00:00:00

abstract：OBJECTIVE:To compare the persistence and costs of brimonidine versus brinzolamide therapy according to data collected by the UK General Practitioner Research Database (GPRD). METHODS:Patients with diagnoses of ocular hypertension or glaucoma, or treated for glaucoma by surgery or laser therapy were identified. Selecte...

journal_title：Journal of medical economics

authors： Lafuma A,Laurendeau C,Berdeaux G

更新日期：2008-01-01 00:00:00

abstract：OBJECTIVE:The objective of the current study was to propose an alternative method for measuring individual operator and peer volumes to use as predictors for adverse outcomes. STUDY DESIGN:A retrospective analysis was performed to assess the volume-outcome relationship for percutaneous coronary intervention (PCI) perf...

journal_title：Journal of medical economics

authors： Xie Y,Rizzo JA,Brown DL

更新日期：2008-01-01 00:00:00